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Duke University approaches the study of the Middle East from an interdisciplinary perspective, encouraging collaboration among scholars across the university. The university offers several undergraduate majors and concentrations, as well as a graduate certificate, allowing students to learn broadly about the Middle East and to specialize in particular cultures, religions and languages.

Duke's International Comparative Studies program also gives students the opportunity to focus their studies on the Middle East and to pair their regional studies with foreign language and study abroad offerings.

Other departments affiliated with DUMESC include the Center for Jewish Studies, Slavic & Eurasian Studies, the history department, and the political science department.